Baseline noise determination method for liquid chromatograph detector
September 20 06:28:43, 2025
It is widely recognized that baseline noise in liquid chromatography detectors is more common than lamp failure. When a deuterium lamp is first turned on, the baseline noise tends to be higher for the first 30 minutes, so it's important to monitor the baseline for at least 30 minutes after each use to ensure stability. Moreover, as the lamp ages, its performance may degrade, leading to increased noise due to reduced energy output.
To identify the source of noise in your liquid chromatograph, consider the following steps:
1. **Re-test the baseline under standard reference conditions** to establish a baseline for comparison. This helps determine if the issue is consistent or intermittent.
2. **Replace suspected detectors** with ones known to be functioning properly. This can help isolate whether the problem lies with the detector itself or another component of the system.
3. **Try replacing the lamp**. Although lamps can be costly, they are often easier to replace than troubleshooting other complex components. If long, persistent noise spikes appear in the chromatogram, you can stop the pump or set the flow rate to 0 mL/min to see if the noise disappears. If the noise stops, it might be caused by bubbles or flow-related issues. However, if the noise remains even after stopping the pump, it could indicate a problem with the lamp. It’s also worth noting that lamp noise can sometimes increase when the pump is running, so this should be considered during diagnosis.
By systematically testing these areas, you can more effectively troubleshoot and resolve baseline noise issues, ensuring accurate and reliable chromatographic results.
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